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Energy metabolism, methylation support, nervous system support
Adults with busy schedules seeking daily B vitamin intake or those with low dietary variety who want support for energy metabolism.
Take 1 capsule 1 to 2 times daily with meals; taking with food may improve tolerance of B vitamins.
Certified Gluten-Free; Non-GMO; Hypoallergenic
Methylcobalamin donates methyl groups for methylation reactions and supports the conversion of homocysteine to methionine, which is important for energy metabolism and nervous system function.
Caution: High-dose B12 may mask folate-related blood changes on lab tests; discuss supplements if you have B12 or folate concerns.
L-5-MTHF is the bioactive folate form used directly in methylation and one-carbon metabolism to support homocysteine remethylation and neurotransmitter synthesis.
Caution: Folate works closely with vitamin B12; imbalances between the two may affect lab markers, so consistent intake patterns matter.
Niacinamide is converted to NAD+/NADP+, coenzymes that drive cellular energy production and redox reactions.
Caution: Flush-free forms typically avoid skin flushing, but high intakes may affect liver enzymes; follow label directions.
Thiamine is a cofactor for enzymes in carbohydrate metabolism, helping convert nutrients into cellular energy (ATP).
Caution: Very high doses can cause mild gastrointestinal discomfort in some people; take with food if sensitive.
Vitamin B6 acts as a coenzyme in amino acid metabolism and neurotransmitter synthesis, and supports homocysteine metabolism via the transsulfuration pathway.
Caution: Excessive long-term B6 intake can cause tingling or numbness; keep within suggested use.
Methylcobalamin and L-5-MTHF work together in methylation to remethylate homocysteine and support neurotransmitter formation. Thiamine, niacinamide and vitamin B6 contribute coenzyme roles that facilitate energy metabolism and amino acid processing, complementing the methylation-focused nutrients.
Label Warning: Natural colour variation may occur. If you are pregnant or breastfeeding, have any health condition or are taking any medication, consult a health professional before use.
Who should be cautious: People with vitamin B12 or folate sensitivity, or those with diagnosed vitamin B metabolism disorders, may wish to discuss use with a healthcare provider. People with a history of sensitivity to high-dose niacin may prefer cautious use with food.
Storage: Store in a cool, dry place.
Helps address mild memory problems associated with normal age-related cognitive decline.
Promotes healthy methylation, a process that maintains healthy gene expression, neurotransmitter production and homocysteine metabolism. Methylation plays important roles in cardiovascular health, neurocognitive health and emotional wellness.
As a food supplement, take 1 capsule, 1-2 times daily, with meals.
Natural colour variation can occur. Product can range from light yellow to bright yellow.
Store in a cool, dry place.
If you are pregnant or breastfeeding, have any health condition or are taking any medication, consult your health professional before use.
Keep out of the reach of children. Use only if safety seal is intact.
Contents may not fill package in order to accommodate required labelling. Please rely on stated quantity.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally be despatched with alternative packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and do not rely solely on the information provided by iHerb. This website has been machine translated as a courtesy to customers. iHerb does not represent or warrant that the translations are complete or error-free and iHerb is not responsible for any translation errors or omissions.
| Supplement information | ||
| Serving Size:1 Capsule | ||
| Servings Per Container:60 | ||
| Amount per serving | %DV | |
| Thiamine (as thiamine HCl) (B1) | 100 mg | 8,333% |
| Riboflavin (as vitamin B2 and 60% riboflavin 5' phospate (activated B2)) | 12.7 mg | 977% |
| Niacin (as niacinamide and 8% Inositol nicotinate (no-flush niacin)) | 108 mg | 675% |
| Vitamin B6 (as pyridoxine HCl and 40% pyridoxal-5-phosphate (activated B6)) | 16.7 mg | 982% |
| Folate (as Metafolin®, L-5-MTHF) | 667 mcg DFE (400 mcg L5-MTHF) | 167% |
| Vitamin B12 (as methylcobalamin) | 400 mcg | 16,667% |
| Biotin | 400 mcg | 1,333% |
| Pantothenic acid (as calcium pantothenate) (B5) | 100 mg | 2,000% |
| %Reference Intake (DV) | ||
Vegetarian capsule (cellulose), water), ascorbyl palmitate.
