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Cardiovascular health, cognitive support, methylation support, homocysteine metabolism
Adults with busy lifestyles who want convenient daily methylation support, or people with limited intake of B vitamins from diet.
Take 3 capsules twice daily, preferably with meals to aid tolerance; spacing doses morning and afternoon may be comfortable for energy-sensitive users.
Gluten Free
Donates methyl groups to remethylate homocysteine to methionine via the betaine-homocysteine methyltransferase pathway.
Caution: May affect fluid balance in some people; take with water and monitor tolerance.
Acts as a cofactor for methionine synthase, which uses methyl groups to convert homocysteine to methionine.
Caution: Very high amounts may be stimulating for some; consider earlier-in-the-day use if sensitive.
Provides the active methyl folate form that supplies methyl groups to support one‑carbon metabolism and homocysteine remethylation.
Caution: High folate may mask signs of low vitamin B12; suitable B12 intake is important.
Serves as the active coenzyme for enzymes in the transsulfuration pathway, helping convert homocysteine through cystathionine to cysteine.
Caution: Large amounts can cause tingling or numbness in some individuals; follow labelled directions.
Betaine and methylcobalamin provide complementary methyl donors and cofactor activity for remethylating homocysteine to methionine, while methyl folate supplies the folate-dependent methyl group. Pyridoxal-5-phosphate supports the alternate transsulfuration route, offering another path for homocysteine utilisation. Together they cover key steps of one‑carbon metabolism.
Label Warning: If pregnant, consult a healthcare practitioner before use.
Who should be cautious: People with high vitamin B intake sensitivity or those on medications that may interact with high-dose B vitamins may wish to discuss suitability with a healthcare provider before use.
Storage: Store tightly sealed in a cool, dry place.
This product is guaranteed authentic and backed by our easy returns and refunds policy. Details
Vitamin B12 and Methylfolate may support energy production and red blood cell formation, working together to maintain healthy homocysteine levels.
AI generated. Not medical advice.
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Supports methylation for a healthy heart, blood vessels, brain, and bones.
Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovascular, cognitive, and bone health. Methylation helps maintain healthy homocysteine levels.
Take 3 capsules twice daily or as recommended by your healthcare practitioner.
Hypromellose (derived from cellulose) capsule,, silicon dioxide, Calcium Citrate, calcium laurate.
Use only if the bottle is sealed. Store tightly sealed in a cool, dry place.
If pregnant, consult your healthcare practitioner before using this product.
Manufactured in the UK using UK & imported ingredients.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally be despatched with alternative packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and do not rely solely on the information provided by iHerb. This website has been machine translated as a courtesy to customers. iHerb does not represent or warrant that the translations are complete or error-free and iHerb is not responsible for any translation errors or omissions.
| Supplement information | ||
| Serving Size:Three Capsules | ||
| Servings Per Container:60 | ||
| Three Capsules Contain: | %DV | |
| Vitamin B6 (as Pyridoxal-5-phosphate) | 20.4 mg | 1,200% |
| Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 2 mg DFE | 500% |
| Vitamin B12 (as methylcobalamin) | 1.2 mg | 50,000% |
| Betaine Anhydrous (Trimethylglycine) | 1.8 g | * |
| *Reference Intake (RI) not established. †This product uses Gnosis S.p.A's L-5-Methyltetrahydrofolic Acid, Glucosamine salt (Quatrefolic®). | ||
